Professor Patrick Anthony Riley Awarded Doctoris Honoris Causa by the Charles Univ ****************************************************************************************** * Professor Patrick Anthony Riley Awarded Doctoris Honoris Causa by the Charles University ****************************************************************************************** Prof. P.A. Riley was born on 22nd March 1935 in Neuilly-sur-Seine in France. He spent his Switzerland where his father, Bertram Hurrel Riley, participated in the founding of the WH studied at University College London and University College Hospital Medical School (UCHMS in 1960. He joined the Department of Dermatological Histopathology at UCHMS as a Rockefell 1963, where he studied  epidermal dendritic cells. By means of the selective melanocytotox hydroxyanisole (a compound that has accompanied dr Riley throughout his scientific career) the distinct lineage of Langerhans cells and melanocytes. In 1965 he defended his Ph.D. th Melanocyte Function“.  From 1966 he worked in the Department of Pathological Chemistry, UCHMS, (which over the ye successively into the Department of Chemical Pathology, the Department of   Biochemical Pa finally, the Department of Molecular Pathology) earning the title of Professor of Cell Pat During this period he shared an office with prof.Trevor Slater, a legendary scientist in t free radicals, and together they published a series of  important papers on various topics pathology, including aspects of the nature of malignancy. The possibility that free radica by defective mitochondria could account for the genetic variability exhibited by malignant the development of a cytological screening test. In a series of other studies, Riley’s res investigated the relationship between cellular motility and proliferation. Also a broad kn natural sciences and laboratory experience prompted prof Riley to suggest that differentia phenomenon emergent from  a series of time-dependent genetic restrictions. The scientific community recognises prof. Riley as a world expert and father of metabolica melanoma therapy using the tyrosinase-catalyzed production of cytotoxic quinones as the ba model compound, 4-hydroxyanisole, reached clinical trial with partial success but, due to pharmacokinetics, the search for further cytotoxic tyrosine analogues has continued. In 19 established the Quintox group, a British-Dutch-Czech association of experts joined by a co quinone toxicity, which, aided by EU funds, produced many significant publications dealing This joint work  generated novel data which has enabled the reformulation of the Raper-Mas melanogenesis, which for fifty years had incorrectly described the biosynthesis of melanin Prof Riley is co-founder (and former Secretary) of the European Society for Pigment Cell R founder (and former Vice-President, Secretary and Treasurer ) of the International Federat Cell Societies, and a present and past member of many Academic Bodies. He is an Honorary M European Society for Pigment Cell Research (1998), and an Honorary Fellow of the Linnean S Prof. Riley was co-founder and, until 2008, Executive Editor of Melanoma Research. He is a member of the editorial boards of several learned journals (British J. Dermatol., Pathobio Cell Research, Tohoku J. of Medical Science, and also Folia Biologica ).   Since the early nineteen eighties prof. Riley has been in active collaboration with the 2n Medical Chemistry and Biochemistry, Faculty of General Medicine, Charles University, namel Duchoň and prof. Borovanský. This long and fruitful cooperation is reflected by many scien the first Monograph in the world devoted to melanosomes which will be published by Wiley/B