Human liver computer model is being tested in Pilsen. It will help to plan better op ****************************************************************************************** * Human liver computer model is being tested in Pilsen. It will help to plan better operat ****************************************************************************************** 16. 2. 2012; by Ivo Dostál; Section: Science at the Charles University The interuniversity team of MUDr. Václav Liška, Ph.D., has been testing a software model o tissue at the Faculty of Medicine in Pilsen which is able to compute the possibilities of of an organ after  large surgery. It should  help mainly oncology patients soon. Software modelling will facilitate the planning of surgeries of both malignant and benign in the liver. In them metastases of colocteral carcinoma, which is the most frequent oncol the Czech Republic, occur. Czechs suffer from this tumour the most in Europe. “After being operated on colocteral carcinoma, the metastases thereof in the liver occur i the patients within 5 years”counts Václav Liška, a young scientist from the Faculty of Med The liver tissue model on which he has been working, together with specialists from the Fa Sciences at the University of West Bohemia, could really help a lot of people. Surgery is the only possibility to save a patient´s life with liver metastases. The liver, a few organs, is able to regenerate relatively well after the intervention. (I would possi the sentence: The liver is one of a few organs which is able to regenerate relatively well intervention)However, the post-operative ability of renewal is different in each person an impossible to foresee it before the operation. Only about one tenth of patients wait to see the operation of liver metastases; with other physicians prefer to refrain from the operation. “The rest of the patients undergo only on the results of which are, however, far from being satisfactory” Liška says. In addition, i impossible to really cure the patients and thus  remove all the leisons without leaving re tumour process”,  adds the scientist and surgeon from the Faculty Hospital in Pilsen whose been sponsored by a European grant - Experimental surgery – new trends in Biomechanics (re CZ1.07/2.2.00/15.0049) . “For instance, in a patient with liver cirrhosis it is not possible to perform liver paren in the same extent as in a patient with healthy parenchyma in which there is ‘only’ a tumo function has not been affected” explains Václav Liška and is one of the reasons why the li model will be so useful. The results of the team of Václav Liška will  make the planning of extensive resection per accurate in patients where there is the threat of emergency liver failure and even the dea  which, due to this, the performance is often refrained from.  “The team of the Faculty of Applied Sciences at the Pilsen University extracts for us liv out of patient data collected at the computed tomography or duplex ultrasonography”, the r European grant, whose team has over  25 specialists, describes the process of research. “W types of blood flow models on it through the liver parenchyma. Our goal is to characterize on these models, the division into particular and to a certain extent autonomous liver sub important at the planning of surgical resections. We also try to estimate the possibilitie potential of liver parenchyma”. Using the model in clinical practice requires long clinical testing. “Currently we stem fr individual patients obtained at the imaging methods and we try to correlate them with real check whether the software model result corresponds with reality”, Liška describes the res believes other faculties of medicine might also profit as, for example, the Faculty of Mat Physics.In the meantime, the experiences with scientific work are gained  mostly by pre gr gradual students from the Faculty of Medicine in Pilsen and the University of West Bohemia to the researcher, have done a decisive part of work on the project. Liška, however, does not only include his students into his project. Besides mathematician University of West Bohemia and specialists from the Clinic of Imaging Methods at the Unive in Pilsen, scientists from the Department of Histology and Embryology and the Department o Faculty of Medicine in Pilsen also work on the research now. “Last but not the least, also surgery clinic liver group,  lead by the professor  Vladislav Třeška, help in the research Liška describes the extensive cooperation. As he says, the problem is very complex and new questions appear virtually every month. Re has been solving the issue of 3D reconstruction of the liver´s capillary system which is c subsequent work. “Currently, we have been getting to know the liver mainly from histological sections, whic only two-dimensional. It is difficult to connect it so that everything corresponds with re Václav Liška, who similarly to most physicians-researchers has devoted himself to the clin  The day begins in the home Pilsen Faculty Hospital by ward  at the Surgery Clinic B Depar evenings and weekends are devoted to the experiments and to scientific work. More information on vena.liska(zavinac)seznam.cz [ MAIL "vena.liska(zavinac)seznam.cz "]